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Easy-X Super Spammer
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Kawasaki Jimbo |
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Polarbear |
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Polarbear Super Spammer
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Posted: 18:38 - 20 Sep 2021 Post subject: |
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Too late for me. I've had 2 and when they offer me a booster, in it goes along with my flu vaccine I had a couple of days ago.
Call me Pincushion Polarbear.
Edited to add, I'm still crap at computers, when do the Microsoft nanonites kick in? ____________________ Triumph Trophy Launch Edition |
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Nobby the Bastard |
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Nobby the Bastard Harley Gaydar
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Ste |
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Ste Not Work Safe
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Posted: 19:54 - 21 Sep 2021 Post subject: |
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Easy-X |
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Andy Perrett |
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Andy Perrett Crazy Courier
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Posted: 15:03 - 10 Nov 2021 Post subject: |
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https://www.youtube.com/watch?v=ufy2AweXRkc&ab_channel=Dr.JohnCampbell
Basically, the "new" Pfizer pill does the same thing as Ivermectin, using the same method, but not as well as Ivermectin.
This comment sums it up perfectly.
Quote: | “No one’s saying that the information has been deliberately hidden away while millions of people have died.” Of course, that’s exactly what he’s saying, and he’s completely right. |
He's basically saying Pfizer added one molecule, patented it and can charge a fortune for it for 30 years, when IM does it better, cheaper and has been approved for human use for decades.
No doubt, Small Penis Syndrome man will scoff, but this bloke knows his stuff.
Profit over lives, yet again.
Quote: | New Pfizer antiviral and ivermectin, a pharmacodynamic analysis
New Pfizer antiviral, PF-07321332, C₂₃H₃₂F₃N₅O₄
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
https://www.pfizer.com/news/press-rel...
So, what is a protease?
So what is a protease inhibitor?
And, what is 3CL?
Chymotrypsin-like protease (3CL main protease, or 3CL Mpro)
Identification of SARS-CoV‑2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening (3rd September 2020)
https://pubs.acs.org/doi/abs/10.1021/...
The activity of the anti-SARS-CoV-2 viral infection was confirmed in 7 of 23 compounds
Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection
https://pubs.rsc.org/en/content/artic...
the strength and persistency of the interaction between IVE and the binding site of 3CLpro indicate that a partial inhibition of the catalytic activity could have place as the drug interacts with the main subdomains that define the enzyme binding pocket:
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
https://www.nature.com/articles/s4200...
as shown in Fig. 4, out of 13 OTDs only ivermectin completely blocked ( more than 80%) the 3CLpro activity at 50 µM concentration.
Development, validation, and approval of COVID-19 specific drugs takes years. Therefore, the idea of drug repositioning, also known as repurposing, is an important strategy to control the sudden outbreak of life-threatening infectious agents that spread rapidly.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
https://pubs.rsc.org/en/content/artic...
From the docking analysis, ivermectin showed the highest docking score with an average energy of −8.5 kcal mol−1 among all the compounds. Remdesivir showed the lowest binding energy and highest docking score of −9.9 kcal mol−1
https://bnf.nice.org.uk/medicinal-for...
Ritonavir, C37H48N6O5S2
Ivermectin, C48H74O14
Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach
https://www.ncbi.nlm.nih.gov/pmc/arti...
We have documented an intense binding of both ivermectin B1a and B1b isomer to the main protease with subsequent energy (ETot-) values of -384.56 and -408.6.
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
https://www.pfizer.com/news/press-rel...
Risk of virus developing resistance to PF-07321332
Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2
https://www.frontiersin.org/articles/...
With SARS-CoV-2 S Spike protein
Ivermectin showed high binding affinity to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2.
In agreement to our findings, ivermectin was found to be docked between the viral spike and the ACE2 receptor
Binding Interactions of Selected Drugs With Human TMPRSS2 Protein (ACE2 protein)
The docking results revealed that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −174.971) and protein–ligand interactions
Binding Interactions of Selected Drugs With Human ACE-2 Protein
that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −159.754) and protein–ligand interactions
With SARS-CoV-2 S Glycoprotein
Ivermectin showed the highest binding affinity to the predicted active site of the protein
With SARS-CoV-2 Nsp14 Protein
ivermectin showed the highest binding affinity (MolDock score −212.265) and protein–ligand interactions
Binding Interactions of Selected Drugs With SARS-CoV-2 PLpro
Ivermectin showed the highest binding affinity to the predicted active site of the protein (MolDock score −180.765) and protein–ligand interactions
A brief message to world leaders
Come on ya all
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Easy-X |
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Easy-X Super Spammer
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Andy Perrett |
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Andy Perrett Crazy Courier
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Posted: 16:32 - 10 Nov 2021 Post subject: |
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Easy-X wrote: | Cable Tie wrote: | Profit over lives, yet again. |
Um, when was there a time this wasn't the case? "Shock News! Company with shareholders seeks profits!"
The problem lies with the corrupt political classes ordering the stuff, "lions led by donkeys" springs to mind. |
The difference here, is that of large Pharma hadn't hatchet jobbed cheap and readily available and approved Ivermectin, using large tech to remove all positive news stories and media to spread propaganda, then they wouldn't have sold their remaining stock of vaccines and millions of lives could have been saved. Literally.
They poured propaganda which was lapped up by the morons, paid the BBC amongst others to fake stories to drag it down as a possible treatment and lobbied governments to refuse it's use for Covid, even when it was fully approved for use in humans.
And the reason? They would have been left with millions of shots of an obsolete vaccine. So instead they're put one molecule into the formula, which they've patented, greased the right palms of government and got it approved in record time, so now instead of cheap IM, we have to buy the thousands of times more expensive PfizerMectin.
They've killed millions and will never face trial, meanwhile the "Horse Worming Pill" Chuckle Brothers will keep their brains switched off and Karma rape this as abusive.
It's one of the largest scandals I can remember and, like China releasing Covid, absolutely nothing will get done about it, as all the large global players are in on the wheeze to some degree, or too weak to fight for justice.
WTF is going on, where we ignore this?
The comments under the video are as pertinent as the content. This guy knows he can't speak against the large pharma, so comes out with comments like... "“No one’s saying that the information has been deliberately hidden away while millions of people have died.”
Of course, that’s exactly what he’s saying, and he’s completely right. |
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Nobby the Bastard |
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Nobby the Bastard Harley Gaydar
Joined: 16 Aug 2013 Karma :
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Posted: 16:35 - 10 Nov 2021 Post subject: |
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Cable Tie wrote: | https://www.youtube.com/watch?v=ufy2AweXRkc&ab_channel=Dr.JohnCampbell
Basically, the "new" Pfizer pill does the same thing as Ivermectin, using the same method, but not as well as Ivermectin.
This comment sums it up perfectly.
Quote: | “No one’s saying that the information has been deliberately hidden away while millions of people have died.” Of course, that’s exactly what he’s saying, and he’s completely right. |
He's basically saying Pfizer added one molecule, patented it and can charge a fortune for it for 30 years, when IM does it better, cheaper and has been approved for human use for decades.
No doubt, Small Penis Syndrome man will scoff, but this bloke knows his stuff.
Profit over lives, yet again.
Quote: | New Pfizer antiviral and ivermectin, a pharmacodynamic analysis
New Pfizer antiviral, PF-07321332, C₂₃H₃₂F₃N₅O₄
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
https://www.pfizer.com/news/press-rel...
So, what is a protease?
So what is a protease inhibitor?
And, what is 3CL?
Chymotrypsin-like protease (3CL main protease, or 3CL Mpro)
Identification of SARS-CoV‑2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening (3rd September 2020)
https://pubs.acs.org/doi/abs/10.1021/...
The activity of the anti-SARS-CoV-2 viral infection was confirmed in 7 of 23 compounds
Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection
https://pubs.rsc.org/en/content/artic...
the strength and persistency of the interaction between IVE and the binding site of 3CLpro indicate that a partial inhibition of the catalytic activity could have place as the drug interacts with the main subdomains that define the enzyme binding pocket:
Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents
https://www.nature.com/articles/s4200...
as shown in Fig. 4, out of 13 OTDs only ivermectin completely blocked ( more than 80%) the 3CLpro activity at 50 µM concentration.
Development, validation, and approval of COVID-19 specific drugs takes years. Therefore, the idea of drug repositioning, also known as repurposing, is an important strategy to control the sudden outbreak of life-threatening infectious agents that spread rapidly.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
https://pubs.rsc.org/en/content/artic...
From the docking analysis, ivermectin showed the highest docking score with an average energy of −8.5 kcal mol−1 among all the compounds. Remdesivir showed the lowest binding energy and highest docking score of −9.9 kcal mol−1
https://bnf.nice.org.uk/medicinal-for...
Ritonavir, C37H48N6O5S2
Ivermectin, C48H74O14
Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach
https://www.ncbi.nlm.nih.gov/pmc/arti...
We have documented an intense binding of both ivermectin B1a and B1b isomer to the main protease with subsequent energy (ETot-) values of -384.56 and -408.6.
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
https://www.pfizer.com/news/press-rel...
Risk of virus developing resistance to PF-07321332
Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2
https://www.frontiersin.org/articles/...
With SARS-CoV-2 S Spike protein
Ivermectin showed high binding affinity to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2.
In agreement to our findings, ivermectin was found to be docked between the viral spike and the ACE2 receptor
Binding Interactions of Selected Drugs With Human TMPRSS2 Protein (ACE2 protein)
The docking results revealed that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −174.971) and protein–ligand interactions
Binding Interactions of Selected Drugs With Human ACE-2 Protein
that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −159.754) and protein–ligand interactions
With SARS-CoV-2 S Glycoprotein
Ivermectin showed the highest binding affinity to the predicted active site of the protein
With SARS-CoV-2 Nsp14 Protein
ivermectin showed the highest binding affinity (MolDock score −212.265) and protein–ligand interactions
Binding Interactions of Selected Drugs With SARS-CoV-2 PLpro
Ivermectin showed the highest binding affinity to the predicted active site of the protein (MolDock score −180.765) and protein–ligand interactions
A brief message to world leaders
Come on ya all
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Ah yes. Dr John who has a PhD in teaching techniques and not medicine.
Your a fuckwit, Marcus. ____________________ trevor saxe-coburg-gotha:"Remember this simple rule - scooters are for men who like to feel the breeze on their huge, flapping cunt lips."
Sprint ST 1050 |
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Andy Perrett |
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Andy Perrett Crazy Courier
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chickenstrip |
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chickenstrip Super Spammer
Joined: 06 Dec 2013 Karma :
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Posted: 16:54 - 10 Nov 2021 Post subject: |
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Nobby the Bastard wrote: |
Your a fuckwit, Marcus. |
Ok. Cut this out or I block you too. Your choice, just to show there are no hard feelings ____________________ Chickenystripgeezer's Biking Life (Latest update 19/10/18) Belgium, France, Italy, Austria tour 2016 Picos de Europa, Pyrenees and French Alps tour 2017 Scotland Trip 1, now with BONUS FEATURE edit, 5/10/19, on page 2 Scotland Trip 2 Luxembourg, Black Forest, Switzerland, Vosges Trip 2017
THERE'S MILLIONS OF CHICKENSTRIPS OUT THERE! |
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Ste |
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Ste Not Work Safe
Joined: 01 Sep 2002 Karma :
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chickenstrip |
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chickenstrip Super Spammer
Joined: 06 Dec 2013 Karma :
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Posted: 17:02 - 10 Nov 2021 Post subject: |
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Ste wrote: | chickenstrip wrote: |
Ok. Cut this out or I block you too. |
What's wrong with calling a spade a spade? |
How many times do you feel you need to do it to get your point across?
Or did you think you were being extremely clever perhaps? ____________________ Chickenystripgeezer's Biking Life (Latest update 19/10/18) Belgium, France, Italy, Austria tour 2016 Picos de Europa, Pyrenees and French Alps tour 2017 Scotland Trip 1, now with BONUS FEATURE edit, 5/10/19, on page 2 Scotland Trip 2 Luxembourg, Black Forest, Switzerland, Vosges Trip 2017
THERE'S MILLIONS OF CHICKENSTRIPS OUT THERE! |
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Ste |
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Ste Not Work Safe
Joined: 01 Sep 2002 Karma :
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Posted: 17:04 - 10 Nov 2021 Post subject: |
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I've only called him it a few times so I don't really care. |
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chickenstrip |
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chickenstrip Super Spammer
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Posted: 17:20 - 10 Nov 2021 Post subject: |
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Ste wrote: | I've only called him it a few times so I don't really care. |
Well, you might have noticed my comment was addressed to Nobby anyway
Although...
It wouldn't be because I don't like you generally, you understand
But jeez, as if my life wasn't a complete borefest as it is right now!
You block one guy, and everyone else just makes sure your efforts are completely ineffective ____________________ Chickenystripgeezer's Biking Life (Latest update 19/10/18) Belgium, France, Italy, Austria tour 2016 Picos de Europa, Pyrenees and French Alps tour 2017 Scotland Trip 1, now with BONUS FEATURE edit, 5/10/19, on page 2 Scotland Trip 2 Luxembourg, Black Forest, Switzerland, Vosges Trip 2017
THERE'S MILLIONS OF CHICKENSTRIPS OUT THERE! |
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Easy-X Super Spammer
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Polarbear Super Spammer
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Kawasaki Jimbo |
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Kawasaki Jimbo World Chat Champion
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Andy Perrett |
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Andy Perrett Crazy Courier
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Kawasaki Jimbo World Chat Champion
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Old Thread Alert!
The last post was made 2 years, 139 days ago. Instead of replying here, would creating a new thread be more useful? |
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