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Visitor Q
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PostPosted: 20:05 - 02 Nov 2006    Post subject: Tuberculosis Reply with quote

Right then, a few things i didnt know that i learnt in a lecture t'other day.

-The BCG injection doesnt stop infection, just stops it from going clinical (ie killing you)

-The BCG only has a roughly 80% success rate anyway on people over the age of 5 (and we all get ours about 12+) and effectiveness goes down with age (ie the older you are when you get the BCG the less it works)

-30'000 cows per year are killed that carry tuberculosis, at a cost of £100million.

-The number is going up.

-The pasteurisation process ISNT 100% safe and regularly breaks down.

AND THE KICKER

The only way to eliminate tuberculosis in cows is to kill every single badger in britain...

Now, am i the only one to have JUST learnt all that?

The bizarre thing is that 100 mill they keep spending on culling would easily pay off long term on the R+D of a vaccine for the badgers.
Oh and the cases rose massively due to foot and mouth since staff were busy bolting all the cows on farms exhibiting the signs, and not doing rounds to all farms checking for other stuff.

Oh and the cases are also on the rise due to cattle being moved all over the uk for minor savings due to subsidies in wales/scotland etc. Should that be stopped?

Oh and by the way its also got one of the highest mutation rates of any pathogens, thus meaning a course of 3 antibiotics have to be used and overseen to avoid resistant strains being formed. How long can we keep that up? Theres no R+D being put into new antibiotics.

Although on the plus side, unless you are clinical (ie coughing up chunks of your lung) you cant transmit it. Although as a beautiful kicker, if you get it clinically, and get the massive quantities of sputum (the stuff you hack up with a cold), if you swallow ANY of it you give yourself a systemic infection which fubars everything LaughingMr. Green

Chirpy stuff eh.

And you thought all i ever did was rant about women and political correctness Wink
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stinkwheel
Bovine Proctologist



Joined: 12 Jul 2004
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PostPosted: 21:20 - 02 Nov 2006    Post subject: Re: Tuberculosis Reply with quote

bonny_ricardo wrote:

The only way to eliminate tuberculosis in cows is to kill every single badger in britain...


Not it isn't. There is no TB in Badgers where there isn't TB in cattle. The results of the two major studies into the likely effectiveness of a badger cull are contradictory to one another. As I recall, neither study was completed properly.

Quote:
Now, am i the only one to have JUST learnt all that?

No. Wink

Quote:
The bizarre thing is that 100 mill they keep spending on culling would easily pay off long term on the R+D of a vaccine for the badgers.

People have been trying to come up with an effective vaccine since the 19th century with no success so far.

Far better to research a decent, rapid, unequivical and highly specific test so we can tell which animals have TB and cull them quickly. The current skin test leaves a lot to be desired but it's all we have.

Quote:
Oh and the cases rose massively due to foot and mouth since staff were busy bolting all the cows on farms exhibiting the signs, and not doing rounds to all farms checking for other stuff.


Not entirely the case. What was more of a problem was the movement of entire herds of cattle back onto culled-out farms from areas known to have a high rate of TB infection WITHOUT TB testing them prior to movement. Myself and others brought this subject directly to the attrention of the chief DEFRA vet in our area on numerous occasions but they proceeded to move the animals anyway. As far as I am concerned, this was a purely political decision, word came down from Whitehall that we had to have animals back on farms before local council elections. As far as I am concerned, the current TB situation in my area is purely of the governments own making.

Quote:
Oh and the cases are also on the rise due to cattle being moved all over the uk for minor savings due to subsidies in wales/scotland etc. Should that be stopped?


All cattle being moved from an area of high TB incidence to an area of lower TB incidence must now have been subjected to an intradermal skin test for TB within 60 days of the movement.

There is very little 'subsidy farming' of cattle as far as I am aware. I think they move cattle about far too much but they tend to be moved for a genuine reason. Unlike sheep. We had to trace over 100,000 different sheep movements arising from only sheep that passed through Hexham livestock market on a single day during the last foot and mouth outbreak.

Quote:
Oh and by the way its also got one of the highest mutation rates of any pathogens, thus meaning a course of 3 antibiotics have to be used and overseen to avoid resistant strains being formed. How long can we keep that up? Theres no R+D being put into new antibiotics.


To an extent, we have a great many antibiotics available that are not currently in use. There was a massive amount of R&D into them in the 1950s and many were 'put to one side' because their side-effects were deemed to outweigh their possible benefits. As medicine has moved on, we are better equipped to deal with these side-effects. Also, beware of confusing mycobacterium bovis with mycobacterium tuberculosis.

Not being a doctor, I have no data as to how many cases of human TB are caused by M. bovis and contracted from cattle but I suspect not many. I would imagine most cases of human TB are caused by M. tuberculosis contracted from other people.

There shouldn't be much antibiotic resistance in M. bovis because we never attempt to treat cattle we suspect are infected.

Here's one for you. Were you aware that just because a beef carcasse has TB lesions, it is not necessarily totally condemned as unfit for human consumption? In reality it would be but there is no legal requirement, in some cases it would be acceptable to discard only some parts of the carcasse.
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Visitor Q
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PostPosted: 10:28 - 03 Nov 2006    Post subject: Reply with quote

Zoonosis stinkwheel. Zoonosis.

The reservoir of m.bovis is in the badgers.

I bought up culling cattle instead, somehow that idea doesnt seem to have been played with yet Laughing

Also m.bovis illicits the same morbidity in humans and the human sp. and all it takes is some idiot coming off antibiotics early and poof.

Also we cant be tasted with we are asymptomatic carriers due to the BCG. But in america i recall there being 15 million people who were asymptomatic carriers wandering about.
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From September 2014 to January/February 2015 I will not be using any English, nor reading any. As such, I won't be on here. PM at will, but I won't be checking/posting unless in emergencies. Certainly not for the first couple of months. Please berate me savagely if I break that rule...
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stinkwheel
Bovine Proctologist



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PostPosted: 14:44 - 03 Nov 2006    Post subject: Reply with quote

Yes, it is a zoonosis. My point was that most cases of human TB will NOT be caused by M. bovis, although it can be. They will be caused by M. tuberculosis which is a disease of humans and will have been caught not from cattle but from other people.

As such, the increasing incidence of TB in humans has little or nothing to do with the incidence of TB in cattle.

It is a concern certainly but regular herd testing, pasteurisation (the temperature of which is increased for herds which have had a TB reactor within the last 12 months) and a comprehensive meat inspection procedure ensures that there is not much chance of bovine TB entering the human population. The people who are most at risk are the farmers themselves who are in constant contact with the cattle and often drink the milk unpasteurised.

For extra credit, look up the tenuous possability of a link between M. paratuberculosis which causes Johnes disease in cattle and sheep and the human condition known as Chrones disease.
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Mister James
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Joined: 10 Aug 2004
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PostPosted: 00:15 - 04 Nov 2006    Post subject: Reply with quote

stinkwheel wrote:

As such, the increasing incidence of TB in humans has little or nothing to do with the incidence of TB in cattle.


Plenty to do with migrants arriving from TB-stricken countries though.


Oops, did I just sounds like a broken record?
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hellkat
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PostPosted: 00:21 - 04 Nov 2006    Post subject: Reply with quote

stinkwheel wrote:
M. paratuberculosis which causes Johnes disease in cattle and sheep and the human condition known as Chrones disease.



Uh oh ... the dreaded "peculiarly-placed aitches in perfectly normal words" virus?

Shocked
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stinkwheel
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PostPosted: 14:27 - 04 Nov 2006    Post subject: Reply with quote

hellkat wrote:

Uh oh ... the dreaded "peculiarly-placed aitches in perfectly normal words" virus?

Shocked


Worse than that. It's actually Johnés (pronounced yonees) disease but I couldn't be arsed looking up the keystroke for the e-acute.
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Clanger
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PostPosted: 14:36 - 04 Nov 2006    Post subject: Reply with quote

I was going to say *phew* soya beans cant catch TB...if it were possible to be transferred from cow to human...

funny how certain illnesses have never been cured by medical science!
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mr jamez
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PostPosted: 19:19 - 04 Nov 2006    Post subject: Reply with quote

How easy is it for cows to spread TB to humans? I am surrounded by them all day.

edit: phew.
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Visitor Q
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PostPosted: 19:49 - 04 Nov 2006    Post subject: Reply with quote

I've clipped a few slides out of the lecture for you to peruse.

(yes i know the data on projected cattle cull costs is an extrapolation and therefore horse shit... but a good indicator anyway)

If anyone wants the full set let me know, the only thing is i obviously dont want to take the piss with my lecturers slide shows, and secondly its 15 meg which will be a pain.

These slides say enough, basically that m.bovis and m.tuberculosis both have the same level of virulence in humans, both cause TB, only difference is its harder to pass on m.bovis.
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China traffic/travel bike vid - When I make a sweeping statement, please add the word 'statistically' in to the sentence before you bitch...
From September 2014 to January/February 2015 I will not be using any English, nor reading any. As such, I won't be on here. PM at will, but I won't be checking/posting unless in emergencies. Certainly not for the first couple of months. Please berate me savagely if I break that rule...
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stinkwheel
Bovine Proctologist



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PostPosted: 14:14 - 05 Nov 2006    Post subject: Reply with quote

Quote:
M. bovis was isolated in 38 out of 7075 cases of bacteriologically confirmed tuberculosis (0.5%) notified to the National Reference Centre (CNR) in 1995

The International Journal of Tuberculosis and Lung Disease, Volume 3, Number 8, August 1999, pp. 711-714(4)

Quote:
Results showed a small, stable incidence of culture positive M. bovis human disease, mean annual incidence 0.56 per 100,000 population compared to a higher but declining incidence of culture positive M. tuberculosis (15.3 per 100,000 in 1983, 9.0 per 100,000 in 1992)

Ir Med J. 1996 Mar-Apr;89(2):62-3.

So. M. bovis is not a major cause of TB in humans.
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gixxersixx
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PostPosted: 17:11 - 05 Nov 2006    Post subject: Reply with quote

For the last four years at least in the london area, children are given the tb vacine in their first year as a matter of course.
Shows how bad things are becoming again with tb
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Mister James
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PostPosted: 17:43 - 05 Nov 2006    Post subject: Reply with quote

And how many cows are there wandering the primary schools of inner city London? The danger comes from, as I said previously, people what wasn't born 'ere - especially as you'll notice many of them have a habit of spitting all over public areas.
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gixxersixx
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PostPosted: 19:00 - 05 Nov 2006    Post subject: Re: Tuberculosis Reply with quote

bonny_ricardo wrote:


-The BCG only has a roughly 80% success rate anyway on people over the age of 5 (and we all get ours about 12+) and effectiveness goes down with age (ie the older you are when you get the BCG the less it works)


this was my point, where you get a major influx into this country of people from countries that have high instances of tb, the bcg is given in the first year after birth, nothing to do with cows wandering around london primary schools, unless you mean the human female cow Laughing
some of the spitting is apparently some religious/cultural thing but theres no excuse for them to spit in public areas, they could carry a small container to spit in but that would be too simple Rolling Eyes
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