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| Irezumi aka Reuben |
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 Irezumi aka Reuben Carrot Top
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| Cigaro |
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 Cigaro World Chat Champion
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| G |
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 G The Voice of Reason
Joined: 02 Feb 2002 Karma :     
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| LeeR |
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 LeeR World Chat Champion

Joined: 12 Dec 2006 Karma :   
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 Posted: 20:04 - 16 May 2008 Post subject: |
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Whilst I ordinarily would take G's advice on board I have to say that from personal experience I found ibuprofen an effective pain killer when I broke my foot because it's very good for soft tissue pain and inflammation.
The best advice I can give you is follow the medical advice to the letter.
Keep you foot elevated, preferably above the level of your heart especially when you sleep.
Use a cold compress of bags of peas or beans (I used soya) wrapped in a tea-towel every hour for about 10-15mins initially then as and when necessary.
Don't neglect your diet eat healthily and drink plenty of fluids, your body will be working hard to repair itself. On this note if you do smoke then stop, restricting blood flow to the small capillaries will slow recovery, and funnily enough smoking does this.
A fractured bone is above all things a soft tissue injury and if you broke it in an impact then the soft tissue will be a longer repair than the bones.
If you have been advised to not bear a load on your foot then heed it, until the advice is to start using it again.
The bone should heal in 6-8 weeks, and then you need to do some exercises to build up strength and loosen up your tendons once again.
I found Deep Freeze Cold Spray also an effective painkiller, in the later stages of recovery when my cast was off and I'd weaned myself off the drugs.
All the best for a steady recovery.  ____________________ My claim to fame: Austin Vince nicked my pen...
Last edited by LeeR on 13:00 - 17 May 2008; edited 1 time in total |
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| Irezumi aka Reuben |
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 Irezumi aka Reuben Carrot Top
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 G The Voice of Reason
Joined: 02 Feb 2002 Karma :     
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| sickpup |
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 sickpup Old Timer

Joined: 21 Apr 2004 Karma :     
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 G The Voice of Reason
Joined: 02 Feb 2002 Karma :     
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 Posted: 09:59 - 17 May 2008 Post subject: |
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I didn't have specific web-resource-links, but just did a basic search on google; the second result was this:
https://www.bmj.com/cgi/content/full/316/7141/1390
| Quote: | Non-steroidal anti-inflammatory drugs are a large class of compounds that inhibit cyclo-oxygenase and thus the formation of prostaglandins, which are involved in bone metabolism. However, the effect of these drugs on bone metabolism is often overlooked. They inhibit osteoblasts at the endosteal bone surface and also reduce both the immune response and the inflammatory response.2 Despite animal studies which have highlighted the harmful effects of these drugs on the healing of fractures 3 4 and spinal fusion,2 they continue to be used commonly for the relief of postoperative pain in the absence of well designed human trials. Furthermore, with the advent of joint prostheses coated with hydroxyapatite, which work by promoting primary bone formation to fill the gap between the prosthesis and the host bone, the use of non-steroidal anti-inflammatory drugs may be counterproductive.
A random survey of the type of analgesia received by patients undergoing hip arthroplasties on our elective orthopaedic ward showed that 95% (18/19) were being treated with these drugs; this treatment had been started immediately after surgery and then had simply continued. Diclofenac sodium or ibuprofen were the most commonly prescribed drugs. Ibuprofen has been shown to have an irreversible effect on the healing of fractures.3 Also the inhibitory effect of these drugs on fracture healing is greater the longer the duration of use. |
The third result, about mice:
https://www.ncbi.nlm.nih.gov/pubmed/2134295
| Quote: | Morphometric and microdensitometric studies on normal bone growth and bone wound healing in growing ICR strain male mice were carried out as preliminary investigations. Then the effects of oral administration of non-steroidal anti-inflammatory drugs on bone growth and bone wound healing were studied. Femur length and width, and bone mineral contents in the femur as judged by microdensitometry of the soft x-ray films of the cortical portion of the femur showed time-dependent linear increase between 3 and 6 weeks of age. Wound holes were made in the parietal bones of mice with a dental bar at 4 weeks of age, and uncalcified area in the holes was determined by image analysis of soft x-ray films. The area decreased their size with the advance in age, especially a marked decrease was observed 2 weeks after the operation. From the above results, 4 week-old male mice were employed and 8 kinds of non-steroidal anti-inflammatory drugs (indomethacin, 1 mg/kg; mefenamic acid, 10 mg/kg; flufenamic acid, 10 mg/kg; diclofenac sodium, 1 mg/kg; ibuprofen, 10 mg/kg; naproxen, 10 mg/kg; phenylbutazone, 10 mg/kg and aspirin, 50 mg/kg) and dexamethasone (1 mg/kg), a steroidal anti-inflammatory drugs were administered orally every day for 9 or 11 days except Sunday, and 15 days after the initial administration, the length and width of the femur were measured. The bone mineral contents were determined by microdensitometry of the soft x-ray film of the femur. Hydroxyproline contents of the femur were also determined. Wound holes were made in the parietal bones at 4 week-old and administered the drugs from one day before the operation for 9 days and the uncalcified area in the wound hole was determined 2 weeks after the operation with an image analyzer. The results obtained were as follows: 1. A significant inhibition of the growth in length of the femur was observed by dexamethasone, diclofenac sodium and naproxen administration for 9 and 11 days. A significant inhibition of the growth in width was also observed by dexamethasone and diclofenac sodium administration for 9 days and by dexamethasone administration for 11 days. |
As they suggest and Brian Simpson mentioned to me; plenty of medical people still haven't considered these studies, but it's definitely not something I'd be willingly taking again.
By the way, I simply searched on google for: >>anti inflammatory bone growth<< which gave lots more results. I'm sure the search could be further fine-tuned. |
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| nrml76 |
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 nrml76 Brolly Dolly

Joined: 05 Nov 2005 Karma :  
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 Posted: 11:09 - 17 May 2008 Post subject: |
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The claim that Non steroidal anti- inflammatory drugs (NSAID's) impair bone healing is not widely accepted by the medical community. If you surveyed the practice of all orthopaedic units across the country, you will find that it is a very very tiny minority of surgeons who think that they are a bad idea. They do have lots of side effects, but are a useful pain killer when taken over short periods.
Like many other pieces of research, it is one of those things that doesn't translate directly from lab studies to clinical experience. NSAID's have been used for decades now for pain relief following both elective and emergency orthopaedic procedures in millions of people without any significant delays in healing.
I can quote you lots papers about drugs that have been shown to have adverse effects in lab studies but no effects in clinical practice. Similarly there are lots of papers which show that drugs very beneficial in lab studies, are not very effective, and sometimes even harmful in clinical practice.
The problem with medical research is that because of the pressure to publish, a lot of studies are set up with a view to getting a result. If the study is not published, it is viewed by both the academics and sponsors as wasted time and money.
Before accepting the results of a study, the methodology and the methods of analysis have to be looked at in detail. Some people just accept results without questioning their validity, while others wait for the weight of their peers opinions to swing one way or the other and a few actually analyse the study in detail for themselves. Unfortunately, not many people in the medical profession do this. Things have changed a bit recently, with doctors getting better at it (mostly younger ones). |
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| lozzypop1 |
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 lozzypop1 Certified MILF!

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 G The Voice of Reason
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| sickpup |
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 sickpup Old Timer

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 sickpup Old Timer

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 G The Voice of Reason
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| Visitor Q |
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 Visitor Q $25 whore

Joined: 30 Apr 2004 Karma :     
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 Posted: 20:41 - 17 May 2008 Post subject: |
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Learn to kick using your shin bones rather then foot? ____________________ China traffic/travel bike vid - When I make a sweeping statement, please add the word 'statistically' in to the sentence before you bitch...
From September 2014 to January/February 2015 I will not be using any English, nor reading any. As such, I won't be on here. PM at will, but I won't be checking/posting unless in emergencies. Certainly not for the first couple of months. Please berate me savagely if I break that rule... |
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 sickpup Old Timer

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| Irezumi aka Reuben |
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 Irezumi aka Reuben Carrot Top
Joined: 28 Sep 2004 Karma :  
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 Posted: 21:20 - 17 May 2008 Post subject: |
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 G The Voice of Reason
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| Visitor Q |
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 Visitor Q $25 whore

Joined: 30 Apr 2004 Karma :     
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 Posted: 23:48 - 17 May 2008 Post subject: |
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| G wrote: |
I appreciate 'scientific' studies often tend to be rather foolishly flawed in their methods and their intentions - I have read enough reports in New Scientist etc where it's obvious the 'researchers' have had a very single-track mind.
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New scientist is usually painfully wrong. Its recent article on evolution had some glaring errors
As for one track mind of researchers, no shit. They'd of heard about the bone inhibition THEN applied for funding to find out if this was true. Its very hard to prove something is wrong, so you rarely get papers going 'results were inconclusive' as it is a waste of space in journals.
So yes, most 'flawed' research set out to prove something.
If you wanted to write an article on the pros and cons of radial verses cross-ply, with the belief that one was inferior, you would obviously set up your tests to see that. If you found fuck all, then it is a boring article. Magazines would probably still publish it as it kills space and they've already paid for alot of the article (tyres, etc). Journals do not work like that. ____________________ China traffic/travel bike vid - When I make a sweeping statement, please add the word 'statistically' in to the sentence before you bitch...
From September 2014 to January/February 2015 I will not be using any English, nor reading any. As such, I won't be on here. PM at will, but I won't be checking/posting unless in emergencies. Certainly not for the first couple of months. Please berate me savagely if I break that rule... |
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| YUN |
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 YUN Traffic Copper

Joined: 08 Jan 2008 Karma :  
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 Posted: 16:20 - 18 May 2008 Post subject: |
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Lorenzo has 2 fractured ankles and still came 2nd. He is seen sucking on Chupa Chups - maybe that'll help
Get well soon  ____________________ Meet the team that will win, Blade, Razor, Blazer and my personal assistant, Michelle and from Romanovia - Fran Stalinovskovichdavidovitchsky
~ * CBT - 13/01/08 --> Theory 24/05/08 --> Squished by lorries, brand new CBR125(2000miles) write-off 04/06/06 --> DAS booked 02-04/08/08 * --> DAS passed 05/08/08 * --> VFR400 (aka 'Mike') ~ |
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| Suitor_Stu |
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 Suitor_Stu Could Be A Chat Bot

Joined: 19 Jun 2006 Karma :  
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 Posted: 08:39 - 19 May 2008 Post subject: |
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| G wrote: | <shrugs> - the information is out there if you want to look for it; I've made people aware of it. It doesn't affect me if people want to listen and look into it for themselves or not. |
Fair enough for showing people the other side, but people should be aware that 100 is still a relatively small number to be considered significant in clinical trials. Without going into great detail the best source for un-biased research for all things medical is the Cochrane Library. The Cochrane Reviews are best - basically what they do is take several randomised control trials (the most un-biased type of trial) and peer-review them - this is to say a group of experts review all the evidence from all the trials and then publish their results in a new report. The sample size for these reviews ranges from 700- 200,000 odd and they are generally quoted religously by people in the know. Their reviews are usually way more objective than single studies alone, but they also review clinical trials too and say what is wrong with them e.g if they need further trials/larger sample size etc.
As such, in my quick search of the library I have not found anything about bone healing and diclofenac in particular, or any other NSAID - or non-steroidal anti-inflammatory drug - to which diclofenac and ibuprofen are members. It does mention what you were talking about with regard to using it to prevent bone growth (in patients after hip operations) but this seems to be a higher dose given in a shorter time compared with for pain relief. There are a few reports which advocate it's use for post operative pain (I know it is routinely advised for post operative dental pain following extraction of teeth where bone healing takes place) but none directly relating to bone healing. Also the prescribing guide for all those in the medical field (the British National Formulary) mentions nothing in it's - extensive - side effect/contra-indications list for NSAIDS about impairment of bone healing. I know this doesn't prove that there is NO link, I'm just giving the other side of the story based on the evidence I have to hand.
FWIW NSAIDs are renound for being exceptionally effective at relieving bone pain, but if you are unsure please ask the advice of the professional you are dealing with. Back to your original question though with regard to helping healing, I would agree with the smoking thing - It has been proven that smoking impairs the blood flow which will in turn mean that the bone will not get as many nutrients meaning it will not heal as quickly. So if you do smoke, you could lay off them if you want a quicker healing time and also eating healthily too - basic things tbh which you're prob sick of hearing but will make a difference!
Hope this helps a little and GWS
Cheers, Stu |
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| nrml76 |
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 nrml76 Brolly Dolly

Joined: 05 Nov 2005 Karma :  
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Old Thread Alert!
The last post was made 18 years, 84 days ago. Instead of replying here, would creating a new thread be more useful? |
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